Mus musculus Protein: Efs
Summary
InnateDB Protein IDBP-162511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efs
Protein Name embryonal Fyn-associated substrate
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000022813
InnateDB Gene IDBG-162509 (Efs)
Protein Structure
UniProt Annotation
Function Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. Higher levels found in placenta and embryo. Lower levels found in brain, brainstem, muscle and lung. No expression in liver and intestine.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
Protein Structure and Domains
PDB ID MGI:105311
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR021901 CAS family, DUF3513
PFAM PF00018
PF14604
PF07653
PF12026
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64355
PhosphoSite PhosphoSite-Q64355
TrEMBL
UniProt Splice Variant
Entrez Gene 13644
UniGene Mm.406568
RefSeq NP_034242
MGI ID
MGI Symbol Efs
OMIM
CCDS CCDS36925
HPRD
IMGT
EMBL AK030321 AK163191 BC005438 U28728 U57686
GenPept AAB02246 AAC52340 AAH05438 BAC26900 BAE37228