InnateDB Protein
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IDBP-16058.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLSTN3
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Protein Name
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calsyntenin 3
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Synonyms
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alcbeta; CDHR14; CSTN3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000266546
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InnateDB Gene
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IDBG-16056 (CLSTN3)
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Protein Structure
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Function |
May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). {ECO:0000269PubMed:12498782, ECO:0000269PubMed:12972431}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002126
Cadherin
IPR008985
Concanavalin A-like lectin/glucanases superfamily
IPR015919
Cadherin-like
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PFAM |
PF00028
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PRINTS |
PR00205
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PIRSF |
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SMART |
SM00112
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BQT9
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PhosphoSite |
PhosphoSite-Q9BQT9
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TrEMBL |
F5H7C7
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UniProt Splice Variant |
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Entrez Gene |
9746
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UniGene |
Hs.535378
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RefSeq |
NP_055533
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HUGO |
HGNC:18371
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OMIM |
611324
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CCDS |
CCDS8575
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HPRD |
16725
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IMGT |
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EMBL |
AB018269
AC018653
AJ277460
AY753302
BC104767
BC111491
BC112283
CH471116
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GenPept |
AAI04768
AAI11492
AAI12284
AAV30552
BAA34446
CAC33084
EAW88677
EAW88678
EAW88679
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