Version 5.4
Homo sapiens Protein: KCTD8
Summary
InnateDB Protein IDBP-16053.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCTD8
Protein Name potassium channel tetramerisation domain containing 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353129
InnateDB Gene IDBG-16051 (KCTD8)
Protein Structure
UniProt Annotation
Function Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0051260 protein homooligomerization
Cellular Component
GO:0030054 cell junction
GO:0042734 presynaptic membrane
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR011333 BTB/POZ fold
PFAM PF02214
PRINTS
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZWB6
PhosphoSite PhosphoSite-Q6ZWB6
TrEMBL B4DQJ9
UniProt Splice Variant
Entrez Gene 386617
UniGene Hs.479644
RefSeq NP_938167
HUGO HGNC:22394
OMIM
CCDS CCDS3467
HPRD 13771
IMGT
EMBL AK123347 AK298831 BC132743 BC136793
GenPept AAI32744 AAI36794 BAC85588 BAG60961

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca