InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psd3

Summary

InnateDB Protein

IDBP-159005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psd3

Protein Name

pleckstrin and Sec7 domain containing 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091178

InnateDB Gene

IDBG-158999 (Psd3)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor for ARF6. {ECO:0000269PubMed:16707115}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:16707115}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in liver. Present in brain, with highest levels in olfactory bulb, cortex, hippocampal pyramidal cell layer and cerebellar granule cell layer (at protein level). {ECO:0000269PubMed:16707115}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity

Biological Process

GO:0030182	neuron differentiation
GO:0032011	ARF protein signal transduction
GO:0032012	regulation of ARF protein signal transduction
GO:0043087	regulation of GTPase activity