InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBP1

Summary

InnateDB Protein

IDBP-15766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP1

Protein Name

insulin-like growth factor binding protein 1

Synonyms

AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12;

Species

Homo sapiens

Ensembl Protein

ENSP00000275525

InnateDB Gene

IDBG-15764 (IGFBP1)

Protein Structure

UniProt Annotation

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. {ECO:0000269PubMed:15972819}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	2 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0030307	positive regulation of cell growth
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0042246	tissue regeneration
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
IPR022322 Insulin-like growth factor-binding protein 1

PFAM

PF00086
PF00219

PRINTS

PR01976
PR01977

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt