InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dok7

Summary

InnateDB Protein

IDBP-156616.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dok7

Protein Name

docking protein 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059538

InnateDB Gene

IDBG-156612 (Dok7)

Protein Structure

UniProt Annotation

Function

Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269PubMed:16794080, ECO:0000269PubMed:20603078}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16794080}; Peripheral membrane protein {ECO:0000269PubMed:16794080}. Cell junction, synapse {ECO:0000269PubMed:16794080}. Note=Accumulates at neuromuscular junctions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0007528	neuromuscular junction development
GO:0043113	receptor clustering
GO:0061098	positive regulation of protein tyrosine kinase activity