Version 5.4
Homo sapiens Protein: BRIX1
Summary
InnateDB Protein IDBP-15583.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRIX1
Protein Name BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338862
InnateDB Gene IDBG-15581 (BRIX1)
Protein Structure
UniProt Annotation
Function Required for biogenesis of the 60S ribosomal subunit.
Subcellular Localization Nucleus, nucleolus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR004154 Anticodon-binding
IPR007109 Brix domain
PFAM PF03129
PF04427
PRINTS
PIRSF
SMART SM00879
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDN6
PhosphoSite PhosphoSite-Q8TDN6
TrEMBL Q9NUW4
UniProt Splice Variant
Entrez Gene 55299
UniGene Hs.718510
RefSeq NP_060791
HUGO HGNC:24170
OMIM
CCDS CCDS34143
HPRD 16563
IMGT
EMBL AF347667 AK001962 AK289610 AY364243 AY364244 BC001546 BC036741 CH471119
GenPept AAH01546 AAH36741 AAL83818 AAQ76802 AAQ76803 BAA92003 BAF82299 EAW55909 EAW55910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca