InnateDB Protein
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IDBP-15323.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EXTL3
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Protein Name
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exostoses (multiple)-like 3
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Synonyms
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BOTV; EXTL1L; EXTR1; REGR; RPR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000220562
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InnateDB Gene
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IDBG-15321 (EXTL3)
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Protein Structure
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Function |
Probable glycosyltransferase (By similarity). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. {ECO:0000250, ECO:0000269PubMed:22727489}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:10639137}; Single-pass type II membrane protein {ECO:0000269PubMed:10639137}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Expressed in keratinocytes. {ECO:0000269PubMed:22727489}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0001888
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glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0046872
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metal ion binding
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Biological Process |
GO:0006987
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activation of signaling protein activity involved in unfolded protein response
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GO:0015012
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heparan sulfate proteoglycan biosynthetic process
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GO:0030307
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positive regulation of cell growth
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0044267
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cellular protein metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR004263
Exostosin-like
IPR015338
EXTL2, alpha-1,4-N-acetylhexosaminyltransferase
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF03016
PF09258
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43909
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PhosphoSite |
PhosphoSite-O43909
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TrEMBL |
E5RIV6
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UniProt Splice Variant |
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Entrez Gene |
2137
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UniGene |
Hs.713320
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RefSeq |
NP_001431
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HUGO |
HGNC:3518
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OMIM |
605744
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CCDS |
CCDS6070
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HPRD |
09306
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IMGT |
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EMBL |
AB007042
AB011091
AC013829
AC131969
AF001690
AF029231
AF083551
AK294475
BC006363
BT007353
CH471080
U76188
U96629
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GenPept |
AAB67602
AAB93670
AAC39598
AAD01877
AAD42041
AAH06363
AAP36017
BAA24080
BAA25445
BAG57702
EAW63507
EAW63508
EAW63509
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