InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCARF1

Summary

InnateDB Protein

IDBP-15127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCARF1

Protein Name

scavenger receptor class F, member 1

Synonyms

SREC; SREC-I; SREC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000323964

InnateDB Gene

IDBG-15121 (SCARF1)

Protein Structure

UniProt Annotation

Function

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006707	cholesterol catabolic process
GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016322	neuron remodeling
GO:0045087	innate immune response (InnateDB)
GO:0048680	positive regulation of axon regeneration