Homo sapiens Protein: TXNDC11
Summary
InnateDB Protein IDBP-14828.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNDC11
Protein Name thioredoxin domain containing 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349439
InnateDB Gene IDBG-14826 (TXNDC11)
Protein Structure
UniProt Annotation
Function May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed at low level. Expressed at higher level in thyroid and prostate. {ECO:0000269PubMed:15561711}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
Biological Process
GO:0006457 protein folding
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PKC3
PhosphoSite PhosphoSite-Q6PKC3
TrEMBL
UniProt Splice Variant
Entrez Gene 51061
UniGene Hs.735457
RefSeq
HUGO HGNC:28030
OMIM
CCDS
HPRD 07125
IMGT
EMBL AF131780 AK027464 AK027646 AK074534 BC002856 BC013727 BC018635 CR457152
GenPept AAD20043 AAH02856 AAH13727 AAH18635 BAB55129 BAB55262 BAC11044 CAG33433