InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ING4

Summary

InnateDB Protein

IDBP-14718.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ING4

Protein Name

inhibitor of growth family, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343396

InnateDB Gene

IDBG-14716 (ING4)

Protein Structure

UniProt Annotation

Function

Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). {ECO:0000269PubMed:12750254, ECO:0000269PubMed:15029197, ECO:0000269PubMed:15251430, ECO:0000269PubMed:15528276, ECO:0000269PubMed:15897452, ECO:0000269PubMed:16387653}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15029197, ECO:0000269PubMed:16973615}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	44 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0006473	protein acetylation
GO:0006915	apoptotic process
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016573	histone acetylation
GO:0043065	positive regulation of apoptotic process
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045926	negative regulation of growth