Version 5.4
Homo sapiens Protein: TUSC5
Summary
InnateDB Protein IDBP-14620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUSC5
Protein Name tumor suppressor candidate 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000329548
InnateDB Gene IDBG-14618 (TUSC5)
Protein Structure
UniProt Annotation
Function May be involved in fat metabolism. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. {ECO:0000269PubMed:12660825}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0009607 response to biotic stimulus
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007593 CD225/Dispanin family
PFAM PF04505
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IXB3
PhosphoSite PhosphoSite-Q8IXB3
TrEMBL
UniProt Splice Variant
Entrez Gene 286753
UniGene Hs.146059
RefSeq NP_758955
HUGO HGNC:29592
OMIM 612211
CCDS CCDS42225
HPRD 18248
IMGT
EMBL AB090231 AC032044 CH471108
GenPept BAC43751 EAW90630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca