InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pygl

Summary

InnateDB Protein

IDBP-145723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pygl

Protein Name

liver glycogen phosphorylase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071231

InnateDB Gene

IDBG-145721 (Pygl)

Protein Structure

UniProt Annotation

Function

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002060	purine nucleobase binding
GO:0004645	phosphorylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0008184	glycogen phosphorylase activity
GO:0016208	AMP binding
GO:0019842	vitamin binding
GO:0030170	pyridoxal phosphate binding
GO:0030246	carbohydrate binding
GO:0032052	bile acid binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005980	glycogen catabolic process
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process
GO:0042593	glucose homeostasis
GO:0070266	necroptotic process