InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Erlin2

Summary

InnateDB Protein

IDBP-145352.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erlin2

Protein Name

ER lipid raft associated 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033873

InnateDB Gene

IDBG-145350 (Erlin2)

Protein Structure

UniProt Annotation

Function

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0030433

ER-associated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome