InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pgam2

Summary

InnateDB Protein

IDBP-145229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pgam2

Protein Name

phosphoglycerate mutase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020768

InnateDB Gene

IDBG-145227 (Pgam2)

Protein Structure

UniProt Annotation

Function

Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

Subcellular Localization

Disease Associations

Tissue Specificity

In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004082	bisphosphoglycerate mutase activity
GO:0004083	bisphosphoglycerate 2-phosphatase activity
GO:0004619	phosphoglycerate mutase activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0048037	cofactor binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006941	striated muscle contraction
GO:0007283	spermatogenesis
GO:0010035	response to inorganic substance
GO:0016311	dephosphorylation
GO:0046689	response to mercury ion