Version 5.4
Mus musculus Protein: Gins4
Summary
InnateDB Protein IDBP-142039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gins4
Protein Name GINS complex subunit 4 (Sld5 homolog)
Synonyms 2810037C03Rik; 4933405K01Rik; Sld5;
Species Mus musculus
Ensembl Protein ENSMUSP00000033950
InnateDB Gene IDBG-142037 (Gins4)
Protein Structure
UniProt Annotation
Function The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16338220}. Nucleus {ECO:0000269PubMed:16338220}.
Disease Associations
Tissue Specificity Highly abundant in testis. Weakly expressed in thymus and bone marrow. {ECO:0000269PubMed:16338220}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1923847
InterPro IPR008591 GINS complex, subunit Sld5
IPR021151 GINS complex
PFAM PF05916
PRINTS
PIRSF PIRSF007764
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LZ3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 109145
UniGene Mm.27945
RefSeq NP_077202
MGI ID
MGI Symbol Gins4
OMIM
CCDS CCDS22190
HPRD
IMGT
EMBL AK076104 AK164815 BC002156
GenPept AAH02156 BAC36185 BAE37931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca