InnateDB Protein
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IDBP-13975.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LTBR
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Protein Name
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lymphotoxin beta receptor (TNFR superfamily, member 3)
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Synonyms
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CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFR3; TNFRSF3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000228918
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InnateDB Gene
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IDBG-13973 (LTBR)
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Protein Structure
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Function |
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. {ECO:0000269PubMed:10799510, ECO:0000269PubMed:8171323}.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
|
Protein-Protein |
28
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
IPR017349
Tumour necrosis factor receptor 3
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PFAM |
PF00020
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PRINTS |
PR01920
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PIRSF |
PIRSF037999
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SMART |
SM00208
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TIGRFAMs |
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Modification |
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SwissProt |
P36941
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PhosphoSite |
PhosphoSite-P36941
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TrEMBL |
Q75UT6
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UniProt Splice Variant |
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Entrez Gene |
4055
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UniGene |
Hs.1116
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RefSeq |
NP_002333
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HUGO |
HGNC:6718
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OMIM |
600979
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CCDS |
CCDS8544
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HPRD |
02988
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IMGT |
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EMBL |
AB125676
AC005840
AK095418
AK293187
BC026262
CH471116
L04270
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GenPept |
AAA36757
AAH26262
BAD01488
BAG53051
BAH11468
EAW88801
EAW88802
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