InnateDB Protein
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IDBP-13729.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLEKHG6
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Protein Name
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pleckstrin homology domain containing, family G (with RhoGef domain) member 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000304640
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InnateDB Gene
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IDBG-13725 (PLEKHG6)
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Protein Structure
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Function |
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269PubMed:16721066, ECO:0000269PubMed:17881735}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR.
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Disease Associations |
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Tissue Specificity |
Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0032321
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positive regulation of Rho GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3KR16
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PhosphoSite |
PhosphoSite-Q3KR16
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55200
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UniGene |
Hs.631660
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RefSeq |
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HUGO |
HGNC:25562
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OMIM |
611743
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CCDS |
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HPRD |
07692
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IMGT |
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EMBL |
AC006057
AF289613
AK001527
AK095373
BC104751
BC105961
BC109095
CH471116
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GenPept |
AAI04752
AAI05962
AAI09096
AAL55797
BAA91741
BAC04539
EAW88809
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