InnateDB Protein
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IDBP-13611.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSMA2
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Protein Name
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proteasome (prosome, macropain) subunit, alpha type, 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000223321
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InnateDB Gene
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IDBG-13609 (PSMA2)
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Protein Structure
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Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.
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Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
168
[view]
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Protein-Protein |
165
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0000209
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protein polyubiquitination
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GO:0000278
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mitotic cell cycle
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0006521
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regulation of cellular amino acid metabolic process
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GO:0006915
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apoptotic process
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GO:0006977
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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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GO:0009615
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response to virus
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0042981
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regulation of apoptotic process
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GO:0043066
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negative regulation of apoptotic process
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GO:0044281
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small molecule metabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051603
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proteolysis involved in cellular protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR000426
Proteasome alpha-subunit, N-terminal domain
IPR001353
Proteasome, subunit alpha/beta
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF10584
PF00227
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PRINTS |
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PIRSF |
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SMART |
SM00948
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TIGRFAMs |
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Modification |
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SwissProt |
P25787
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PhosphoSite |
PhosphoSite-P25787
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TrEMBL |
Q6MZI6
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UniProt Splice Variant |
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Entrez Gene |
5683
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UniGene |
Hs.628502
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RefSeq |
NP_002778
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HUGO |
HGNC:9531
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OMIM |
176842
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CCDS |
CCDS5467
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HPRD |
08907
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IMGT |
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EMBL |
AC010132
AK290654
BC002900
BC047697
BX641097
CH236951
CH471073
CR450317
D00760
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GenPept |
AAH02900
AAH47697
BAA00657
BAF83343
CAE46046
CAG29313
EAL24005
EAW94151
EAW94152
EAW94153
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