InnateDB Protein
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IDBP-13288.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP6R2
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Protein Name
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protein phosphatase 6, regulatory subunit 2
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Synonyms
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KIAA0685; PP6R2; SAP190; SAPS2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352051
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InnateDB Gene
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IDBG-13286 (PPP6R2)
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Protein Structure
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Function |
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269PubMed:16769727}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16769727}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta. {ECO:0000269PubMed:16769727}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
48
[view]
|
Protein-Protein |
48
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007587
SIT4 phosphatase-associated protein family
IPR016024
Armadillo-type fold
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PFAM |
PF04499
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75170
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PhosphoSite |
PhosphoSite-O75170
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9701
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UniGene |
Hs.729287
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RefSeq |
NP_001229829
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HUGO |
HGNC:19253
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OMIM |
610877
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CCDS |
CCDS56236
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HPRD |
11102
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IMGT |
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EMBL |
AB014585
AK302472
AL096767
AL671545
AL954743
BC000976
BC006568
BC032664
BC041698
BC052995
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GenPept |
AAH00976
AAH06568
AAH32664
AAH41698
AAH52995
BAA31660
BAH13719
CAO03456
CAO03457
CAO03458
CAO03459
CAO03561
CAO03562
CAO03563
CAO03564
CAO03642
CAO03643
CAO03644
CAO03645
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