InnateDB Protein
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IDBP-132810.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Litaf
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Protein Name
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LPS-induced TN factor
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Synonyms
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3222402J11Rik; C85531; N4WBP3; TBX1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000023143
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InnateDB Gene
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IDBG-132808 (Litaf)
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Protein Structure
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Function |
Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. {ECO:0000269PubMed:12355436, ECO:0000269PubMed:15025820}.
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Subcellular Localization |
Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with membranes of lysosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in liver. {ECO:0000269PubMed:12355436, ECO:0000269PubMed:15025820}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929512
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InterPro |
IPR006629
LPS-induced tumor necrosis factor alpha factor
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PFAM |
PF10601
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PRINTS |
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PIRSF |
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SMART |
SM00714
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JLJ0
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PhosphoSite |
PhosphoSite-Q9JLJ0
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TrEMBL |
E0CYR5
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UniProt Splice Variant |
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Entrez Gene |
56722
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UniGene |
Mm.466843
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RefSeq |
NP_064364
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MGI ID |
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MGI Symbol |
Litaf
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OMIM |
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CCDS |
CCDS27958
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HPRD |
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IMGT |
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EMBL |
AC164093
AF171100
AF220207
AF230522
AK018578
AK076162
AK151053
AK159533
BC018559
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GenPept |
AAF27312
AAG44246
AAH18559
AAO49168
BAB31289
BAC36228
BAE30070
BAE35161
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