InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPYSL2

Summary

InnateDB Protein

IDBP-13204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYSL2

Protein Name

dihydropyrimidinase-like 2

Synonyms

CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000309539

InnateDB Gene

IDBG-13200 (DPYSL2)

Protein Structure

UniProt Annotation

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269PubMed:11477421, ECO:0000269PubMed:15466863, ECO:0000269PubMed:20801876}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:20801876}. Membrane {ECO:0000269PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004157	dihydropyrimidinase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019901	protein kinase binding

Biological Process

GO:0001975	response to amphetamine
GO:0006139	nucleobase-containing compound metabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007420	brain development
GO:0014049	positive regulation of glutamate secretion
GO:0021510	spinal cord development
GO:0021772	olfactory bulb development
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0045664	regulation of neuron differentiation
GO:0048489	synaptic vesicle transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome