InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFA9

Summary

InnateDB Protein

IDBP-13150.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA9

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

Synonyms

CC6; CI-39k; CI39k; NDUFS2L; SDR22E1;

Species

Homo sapiens

Ensembl Protein

ENSP00000266544

InnateDB Gene

IDBG-13148 (NDUFA9)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0032403	protein complex binding
GO:0050662	coenzyme binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0006694	steroid biosynthetic process
GO:0006814	sodium ion transport
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0005759	mitochondrial matrix
GO:0031966	mitochondrial membrane