InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Peli3

Summary

InnateDB Protein

IDBP-130438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Peli3

Protein Name

pellino 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025834

InnateDB Gene

IDBG-130436 (Peli3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0008063	Toll signaling pathway
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0045751	negative regulation of Toll signaling pathway
GO:0050829	defense response to Gram-negative bacterium
GO:0070428	regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070534	protein K63-linked ubiquitination
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway