Version 5.4
| Mus musculus Protein: Dsg4 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-129909.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Dsg4 | ||||||||||||
| Protein Name | desmoglein 4 | ||||||||||||
| Synonyms | CDHF13; lah; | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Protein | ENSMUSP00000019426 | ||||||||||||
| InnateDB Gene | IDBG-129907 (Dsg4) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. {ECO:0000269PubMed:12705872}. | ||||||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}. | ||||||||||||
| Disease Associations | Note=Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah). Lah mice pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within a few month. They have thickened skin and do not exhibit any growth retardation. | ||||||||||||
| Tissue Specificity | Strongly expressed in the skin; during the anagen stage of hair follicles in the matrix, precortex and inner rooth sheath. {ECO:0000269PubMed:12787123}. | ||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | MGI:2661061 | ||||||||||||
| InterPro |
IPR000233
Cadherin, cytoplasmic domain IPR002126 Cadherin IPR009122 Desmosomal cadherin IPR009123 Desmoglein IPR015919 Cadherin-like |
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| PFAM |
PF01049
PF00028 |
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| PRINTS |
PR00205
PR01818 PR01819 |
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| PIRSF | |||||||||||||
| SMART |
SM00112
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| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q7TMD7 | ||||||||||||
| PhosphoSite | PhosphoSite-Q7TMD7 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 16769 | ||||||||||||
| UniGene | |||||||||||||
| RefSeq | NP_853543 | ||||||||||||
| MGI ID | |||||||||||||
| MGI Symbol | Dsg4 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS29082 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | AY191584 AY227349 | ||||||||||||
| GenPept | AAO91793 AAP44999 | ||||||||||||