InnateDB Protein
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IDBP-12948.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MGRN1
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Protein Name
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mahogunin, ring finger 1
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Synonyms
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RNF156;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262370
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InnateDB Gene
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IDBG-12946 (MGRN1)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269PubMed:17229889, ECO:0000269PubMed:19703557, ECO:0000269PubMed:19737927}.
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Subcellular Localization |
Early endosome {ECO:0000269PubMed:17229889, ECO:0000269PubMed:19737927}. Note=The endosomal localization is dependent on the interaction with TSG101.Isoform 1: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.Isoform 3: Cytoplasm, cytosol. Cell membrane.Isoform 4: Cytoplasm, cytosol. Cell membrane.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
32
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0000209
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protein polyubiquitination
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GO:0006513
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protein monoubiquitination
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GO:0008333
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endosome to lysosome transport
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GO:0043951
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negative regulation of cAMP-mediated signaling
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GO:0045744
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negative regulation of G-protein coupled receptor protein signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
O60291
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PhosphoSite |
PhosphoSite-O60291
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TrEMBL |
K7ERA1
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UniProt Splice Variant |
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Entrez Gene |
23295
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UniGene |
Hs.526494
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RefSeq |
NP_056061
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HUGO |
HGNC:20254
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OMIM |
607559
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CCDS |
CCDS42115
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HPRD |
07397
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IMGT |
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EMBL |
AB011116
AC023830
BC050389
EF471397
EF471398
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GenPept |
AAH50389
ABO69623
ABO69624
BAA25470
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