InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMPH

Summary

InnateDB Protein

IDBP-12923.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMPH

Protein Name

amphiphysin

Synonyms

AMPH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000317441

InnateDB Gene

IDBG-12921 (AMPH)

Protein Structure

UniProt Annotation

Function

May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Neurons, certain endocrine cell types and spermatocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0006897	endocytosis
GO:0007268	synaptic transmission

Cellular Component

GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031256	leading edge membrane