InnateDB Protein
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IDBP-12917.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMED10
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Protein Name
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transmembrane emp24-like trafficking protein 10 (yeast)
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Synonyms
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p23; P24(DELTA); S31I125; S31III125; Tmp-21-I; TMP21;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303145
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InnateDB Gene
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IDBG-12915 (TMED10)
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Protein Structure
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Function |
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus. {ECO:0000250, ECO:0000269PubMed:10052452, ECO:0000269PubMed:11726511, ECO:0000269PubMed:16641999, ECO:0000269PubMed:17288597, ECO:0000269PubMed:19296914, ECO:0000269PubMed:20427317, ECO:0000269PubMed:21219331}.
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Subcellular Localization |
Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Melanosome. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Cycles between compartments of the early secretatory pathway.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009038
GOLD
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PFAM |
PF01105
PF13897
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49755
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PhosphoSite |
PhosphoSite-P49755
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TrEMBL |
B4DZH3
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UniProt Splice Variant |
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Entrez Gene |
10972
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UniGene |
Hs.74137
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RefSeq |
NP_006818
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HUGO |
HGNC:16998
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OMIM |
605406
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CCDS |
CCDS9840
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HPRD |
12013
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IMGT |
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EMBL |
AC007055
AJ004913
AK302920
AK312384
AL832012
BC001496
BC001825
BX248754
CH471061
L40397
U61734
X97442
X97444
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GenPept |
AAB03625
AAC42003
AAD31941
AAH01496
AAH01825
BAG35302
BAG64085
CAA06213
CAA66071
CAA66073
CAD66561
CAD89913
EAW81223
EAW81225
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