InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCND2

Summary

InnateDB Protein

IDBP-12914.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCND2

Protein Name

cyclin D2

Synonyms

KIAK0002; MPPH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000261254

InnateDB Gene

IDBG-12912 (CCND2)

Protein Structure

UniProt Annotation

Function

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18827403}. Cytoplasm {ECO:0000269PubMed:18827403}. Membrane {ECO:0000269PubMed:18827403}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	27 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001934	positive regulation of protein phosphorylation
GO:0007049	cell cycle
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301	cell division
GO:0051726	regulation of cell cycle

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0031965	nuclear membrane