InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il7r

Summary

InnateDB Protein

IDBP-129137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il7r

Protein Name

interleukin 7 receptor

Synonyms

CD127; IL-7Ralpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003981

InnateDB Gene

IDBG-129135 (Il7r)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Spleen, thymus and fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	6 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0002377	immunoglobulin production
GO:0008361	regulation of cell size
GO:0010628	positive regulation of gene expression
GO:0016049	cell growth
GO:0019221	cytokine-mediated signaling pathway
GO:0030217	T cell differentiation
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0042100	B cell proliferation
GO:0048535	lymph node development
GO:0048872	homeostasis of number of cells