InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npc1

Summary

InnateDB Protein

IDBP-128879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npc1

Protein Name

Niemann Pick type C1

Synonyms

A430089E03Rik; C85354; D18Ertd139e; D18Ertd723e; lcsd; nmf164; spm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025279

InnateDB Gene

IDBG-128877 (Npc1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0015485	cholesterol binding

Biological Process

GO:0006486	protein glycosylation
GO:0006897	endocytosis
GO:0006914	autophagy
GO:0007041	lysosomal transport
GO:0007165	signal transduction
GO:0007628	adult walking behavior
GO:0008203	cholesterol metabolic process
GO:0008206	bile acid metabolic process
GO:0016242	negative regulation of macroautophagy
GO:0030301	cholesterol transport
GO:0031579	membrane raft organization
GO:0033344	cholesterol efflux
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0046686	response to cadmium ion
GO:0060548	negative regulation of cell death
GO:0071383	cellular response to steroid hormone stimulus
GO:0071404	cellular response to low-density lipoprotein particle stimulus
GO:0090150	establishment of protein localization to membrane

Cellular Component

GO:0005576	extracellular region
GO:0005635	nuclear envelope
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0031982	vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome