InnateDB Protein
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IDBP-12857.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HMOX2
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Protein Name
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heme oxygenase (decycling) 2
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Synonyms
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HO-2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000219700
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InnateDB Gene
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IDBG-12855 (HMOX2)
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Protein Structure
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Function |
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
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Subcellular Localization |
Microsome. Endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
56
[view]
|
Protein-Protein |
55
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002051
Haem oxygenase
IPR016053
Haem oxygenase-like
IPR016084
Haem oxygenase-like, multi-helical
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PFAM |
PF01126
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PRINTS |
PR00088
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PIRSF |
PIRSF000343
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P30519
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PhosphoSite |
PhosphoSite-P30519
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TrEMBL |
I3L4P8
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UniProt Splice Variant |
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Entrez Gene |
3163
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UniGene |
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RefSeq |
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HUGO |
HGNC:5014
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OMIM |
141251
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CCDS |
CCDS10517
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HPRD |
00783
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IMGT |
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EMBL |
AC007606
AF051306
AY771350
BC002396
BT019788
CH471112
D21243
S34389
W38932
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GenPept |
AAB22110
AAC05297
AAH02396
AAV28730
AAV38591
BAA04789
EAW85299
EAW85300
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