InnateDB Protein
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IDBP-12852.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTBP1
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Protein Name
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polypyrimidine tract binding protein 1
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Synonyms
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HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349428
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InnateDB Gene
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IDBG-12848 (PTBP1)
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Protein Structure
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Function |
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269PubMed:11003644, ECO:0000269PubMed:15009664, ECO:0000269PubMed:16179478, ECO:0000269PubMed:16260624, ECO:0000269PubMed:21518792}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
123
[view]
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Protein-Protein |
119
[view]
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Protein-DNA |
0
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Protein-RNA |
4
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR006536
HnRNP-L/PTB/hephaestus splicing factor
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P26599
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PhosphoSite |
PhosphoSite-P26599
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5725
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UniGene |
Hs.616689
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RefSeq |
NP_002810
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HUGO |
HGNC:9583
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OMIM |
600693
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CCDS |
CCDS42456
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HPRD |
02823
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IMGT |
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EMBL |
AC006273
BC002397
BC004383
BC013694
BT006819
CH471242
X60648
X62006
X65371
X65372
X66975
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GenPept |
AAC99798
AAH02397
AAH04383
AAH13694
AAP35465
CAA43056
CAA43973
CAA46443
CAA46444
CAA47386
EAW61154
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