InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTBP1

Summary

InnateDB Protein

IDBP-12850.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTBP1

Protein Name

polypyrimidine tract binding protein 1

Synonyms

HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4;

Species

Homo sapiens

Ensembl Protein

ENSP00000014112

InnateDB Gene

IDBG-12848 (PTBP1)

Protein Structure

UniProt Annotation

Function

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269PubMed:11003644, ECO:0000269PubMed:15009664, ECO:0000269PubMed:16179478, ECO:0000269PubMed:16260624, ECO:0000269PubMed:21518792}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	123 [view]
Protein-Protein	119 [view]
Protein-DNA	0
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008187	poly-pyrimidine tract binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0033119	negative regulation of RNA splicing
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0051148	negative regulation of muscle cell differentiation