InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rictor

Summary

InnateDB Protein

IDBP-128170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rictor

Protein Name

RPTOR independent companion of MTOR, complex 2

Synonyms

4921505C17Rik; 6030405M08Rik; AVO3; AW492497; D530039E11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051809

InnateDB Gene

IDBG-128168 (Rictor)

Protein Structure

UniProt Annotation

Function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269PubMed:16221682, ECO:0000269PubMed:16962653, ECO:0000269PubMed:16962829, ECO:0000269PubMed:17141160}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0009790	embryo development
GO:0030838	positive regulation of actin filament polymerization
GO:0031532	actin cytoskeleton reorganization
GO:0031929	TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0032314	regulation of Rac GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0042325	regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896	regulation of protein kinase B signaling
GO:0051897	positive regulation of protein kinase B signaling