InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIM3

Summary

InnateDB Protein

IDBP-12686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIM3

Protein Name

pim-3 oncogene

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353824

InnateDB Gene

IDBG-12684 (PIM3)

Protein Structure

UniProt Annotation

Function

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269PubMed:15540201, ECO:0000269PubMed:16818649, ECO:0000269PubMed:17270021, ECO:0000269PubMed:17876606, ECO:0000269PubMed:18593906}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17876606}.

Disease Associations

Tissue Specificity

Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269PubMed:15540201, ECO:0000269PubMed:16818649, ECO:0000269PubMed:17270021}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007346	regulation of mitotic cell cycle
GO:0009103	lipopolysaccharide biosynthetic process
GO:0016572	histone phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt