InnateDB Protein
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IDBP-12357.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BSG
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Protein Name
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basigin (Ok blood group)
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Synonyms
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5F7; CD147; EMMPRIN; M6; OK; TCSF;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344707
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InnateDB Gene
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IDBG-12353 (BSG)
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Protein Structure
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Function |
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO:0000269PubMed:17127621}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013098
Immunoglobulin I-set
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PFAM |
PF07679
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
P35613
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PhosphoSite |
PhosphoSite-P35613
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TrEMBL |
R4GN83
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UniProt Splice Variant |
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Entrez Gene |
682
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UniGene |
Hs.716791
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RefSeq |
NP_940993
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HUGO |
HGNC:1116
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OMIM |
109480
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CCDS |
CCDS12032
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HPRD |
00176
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IMGT |
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EMBL |
AB072923
AB085790
AC005559
AC009005
AF042848
AF042849
AF042850
AF042851
AF042852
AF042853
AF042854
AF548371
AY358113
AY942196
BC009040
CH471242
D45131
GU557064
GU557065
L10240
L20471
M87879
X64364
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GenPept |
AAA68936
AAA91084
AAB41120
AAC33279
AAD10704
AAH09040
AAN40694
AAQ88480
AAX20110
ADD31881
ADD31882
BAA08109
BAB88938
BAC76828
CAA45716
EAW61181
EAW61185
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