InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA5A

Summary

InnateDB Protein

IDBP-12175.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA5A

Protein Name

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

Synonyms

SEMAF; semF;

Species

Homo sapiens

Ensembl Protein

ENSP00000371936

InnateDB Gene

IDBG-12173 (SEMA5A)

Protein Structure

UniProt Annotation

Function

Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269PubMed:15218527, ECO:0000269PubMed:19850054, ECO:0000269PubMed:20696765, ECO:0000269PubMed:21706053}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008046	axon guidance receptor activity
GO:0030215	semaphorin receptor binding
GO:0035373	chondroitin sulfate proteoglycan binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0045545	syndecan binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0021536	diencephalon development
GO:0030836	positive regulation of actin filament depolymerization
GO:0035413	positive regulation of catenin import into nucleus
GO:0045766	positive regulation of angiogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050918	positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling
GO:0060326	cell chemotaxis
GO:1990256	signal clustering
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2001028	positive regulation of endothelial cell chemotaxis