InnateDB Protein
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IDBP-12163.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLX4
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Protein Name
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SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000294008
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InnateDB Gene
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IDBG-12161 (SLX4)
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Protein Structure
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Function |
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure- specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81- EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. {ECO:0000269PubMed:19595721, ECO:0000269PubMed:19595722, ECO:0000269PubMed:19596235, ECO:0000269PubMed:19596236}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:19596235, ECO:0000269PubMed:19596236}. Note=Localizes to sites of DNA dammage.
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Disease Associations |
Fanconi anemia complementation group P (FANCP) [MIM:613951]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some individuals affected by Fanconi anemia of complementation group P have skeletal anomalies. {ECO:0000269PubMed:21240275, ECO:0000269PubMed:21240277}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
52
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000724
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double-strand break repair via homologous recombination
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GO:0000737
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DNA catabolic process, endonucleolytic
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GO:0006260
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DNA replication
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GO:0006281
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DNA repair
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GO:0006289
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nucleotide-excision repair
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GO:0010792
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DNA double-strand break processing involved in repair via single-strand annealing
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GO:0043085
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positive regulation of catalytic activity
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GO:0045087
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innate immune response (InnateDB)
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GO:0072429
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response to intra-S DNA damage checkpoint signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR000210
BTB/POZ-like
IPR011333
BTB/POZ fold
IPR013069
BTB/POZ
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PFAM |
PF00651
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PRINTS |
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PIRSF |
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SMART |
SM00225
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IY92
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PhosphoSite |
PhosphoSite-Q8IY92
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84464
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UniGene |
Hs.143681
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RefSeq |
NP_115820
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HUGO |
HGNC:23845
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OMIM |
613278
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CCDS |
CCDS10506
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HPRD |
12537
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IMGT |
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EMBL |
AB058687
AB075867
AC006111
AL442083
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GenPept |
BAB47413
BAB85573
CAH10659
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