InnateDB Protein
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IDBP-12010.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPAP2C
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Protein Name
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phosphatidic acid phosphatase type 2C
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Synonyms
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LPP2; PAP-2c; PAP2-g;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000269812
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InnateDB Gene
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IDBG-12008 (PPAP2C)
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Protein Structure
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Function |
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Found mainly in brain, pancreas and placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000326
Phosphatidic acid phosphatase type 2/haloperoxidase
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PFAM |
PF01569
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PRINTS |
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PIRSF |
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SMART |
SM00014
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TIGRFAMs |
|
Modification |
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SwissProt |
O43688
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PhosphoSite |
PhosphoSite-O43688
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TrEMBL |
|
UniProt Splice Variant |
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Entrez Gene |
8612
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UniGene |
|
RefSeq |
NP_803545
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HUGO |
HGNC:9230
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OMIM |
607126
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CCDS |
CCDS45889
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HPRD |
06180
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IMGT |
|
EMBL |
AC016588
AF035959
AF047760
AF056083
BC002806
BT007021
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GenPept |
AAC15968
AAC25666
AAC32104
AAH02806
AAP35667
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