InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS1

Summary

InnateDB Protein

IDBP-1194.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS1

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 1

Synonyms

C3-C5; METH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000284984

InnateDB Gene

IDBG-1192 (ADAMTS1)

Protein Structure

UniProt Annotation

Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. {ECO:0000250, ECO:0000269PubMed:10438512}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0001822	kidney development
GO:0006508	proteolysis
GO:0007229	integrin-mediated signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0060347	heart trabecula formation

Cellular Component

GO:0005604	basement membrane
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
IPR010294 ADAM-TS Spacer 1
IPR013273 Peptidase M12B, ADAM-TS
IPR013274 Peptidase M12B, ADAM-TS1

PFAM

PF00090
PF01421
PF01562
PF08516
PF05986

PRINTS

PR01857
PR01858

PIRSF

SMART

SM00209
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt