InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPARGC1A

Summary

InnateDB Protein

IDBP-11760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARGC1A

Protein Name

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Synonyms

LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000264867

InnateDB Gene

IDBG-11756 (PPARGC1A)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. {ECO:0000269PubMed:10713165, ECO:0000269PubMed:20005308, ECO:0000269PubMed:21376232, ECO:0000269PubMed:23836911}.

Subcellular Localization

Isoform 1: Nucleus. Nucleus, PML body.Isoform B4: Nucleus.Isoform B4-8a: Cytoplasm. Nucleus.Isoform B5: Nucleus. Nucleus, PML body.Isoform 9: Nucleus {ECO:0000269PubMed:22009745}.

Disease Associations

Tissue Specificity

Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. {ECO:0000269PubMed:10585775, ECO:0000269PubMed:10643692, ECO:0000269PubMed:10713165}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	79 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001666	response to hypoxia
GO:0001678	cellular glucose homeostasis
GO:0006012	galactose metabolic process
GO:0006094	gluconeogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0006461	protein complex assembly
GO:0007005	mitochondrion organization
GO:0007586	digestion
GO:0008209	androgen metabolic process
GO:0008380	RNA splicing
GO:0009409	response to cold
GO:0010822	positive regulation of mitochondrion organization
GO:0010941	regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0014850	response to muscle activity
GO:0019395	fatty acid oxidation
GO:0022904	respiratory electron transport chain
GO:0030521	androgen receptor signaling pathway
GO:0031325	positive regulation of cellular metabolic process
GO:0031667	response to nutrient levels
GO:0032922	circadian regulation of gene expression
GO:0034599	cellular response to oxidative stress
GO:0035066	positive regulation of histone acetylation
GO:0036273	response to statin
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0042752	regulation of circadian rhythm
GO:0043201	response to leucine
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045333	cellular respiration
GO:0045722	positive regulation of gluconeogenesis
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050821	protein stabilization
GO:0050873	brown fat cell differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051552	flavone metabolic process
GO:0070997	neuron death
GO:0071250	cellular response to nitrite
GO:0071356	cellular response to tumor necrosis factor
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071871	response to epinephrine
GO:0071873	response to norepinephrine
GO:0097067	cellular response to thyroid hormone stimulus
GO:1901857	positive regulation of cellular respiration
GO:1901860	positive regulation of mitochondrial DNA metabolic process
GO:1901863	positive regulation of muscle tissue development
GO:2000272	negative regulation of receptor activity
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000507	positive regulation of energy homeostasis
GO:2001171	positive regulation of ATP biosynthetic process