Version 5.4
Homo sapiens Protein: TNFRSF10D
Summary
InnateDB Protein IDBP-11636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF10D
Protein Name tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
Synonyms CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD;
Species Homo sapiens
Ensembl Protein ENSP00000310263
InnateDB Gene IDBG-11632 (TNFRSF10D)
Protein Structure
UniProt Annotation
Function Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001368 TNFR/NGFR cysteine-rich region
IPR020465 Tumour necrosis factor receptor 10
PFAM PF00020
PRINTS PR01956
PIRSF PIRSF037867
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBN6
PhosphoSite PhosphoSite-Q9UBN6
TrEMBL
UniProt Splice Variant
Entrez Gene 8793
UniGene Hs.213467
RefSeq NP_003831
HUGO HGNC:11907
OMIM 603614
CCDS CCDS6038
HPRD 04682
IMGT
EMBL AF021232 AF021233 AF023849 AF029761 AK313528 AY358285 BC052270
GenPept AAC32765 AAC32766 AAC52053 AAD03477 AAH52270 AAQ88652 BAG36307

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca