Version 5.4
Homo sapiens Protein: TNFRSF10C
Summary
InnateDB Protein IDBP-11574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF10C
Protein Name tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Synonyms CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID;
Species Homo sapiens
Ensembl Protein ENSP00000349324
InnateDB Gene IDBG-11572 (TNFRSF10C)
Protein Structure
UniProt Annotation
Function Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0045569 TRAIL binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001368 TNFR/NGFR cysteine-rich region
IPR020465 Tumour necrosis factor receptor 10
PFAM PF00020
PRINTS PR01956
PIRSF PIRSF037867
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14798
PhosphoSite PhosphoSite-O14798
TrEMBL F5H6H7
UniProt Splice Variant
Entrez Gene 8794
UniGene Hs.735240
RefSeq NP_003832
HUGO HGNC:11906
OMIM 603613
CCDS CCDS6037
HPRD 04681
IMGT
EMBL AC107959 AF012536 AF012629 AF014794 AF016267 AF020502 AF033854 AY358281 BC125041 BC125042 CR541857
GenPept AAB67104 AAB67110 AAB71413 AAB81181 AAB87506 AAC05593 AAI25042 AAI25043 AAQ88648 CAG46655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca