Version 5.4
Homo sapiens Protein: PSMG2
Summary
InnateDB Protein IDBP-1152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMG2
Protein Name proteasome (prosome, macropain) assembly chaperone 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000325919
InnateDB Gene IDBG-1148 (PSMG2)
Protein Structure
UniProt Annotation
Function Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269PubMed:16251969, ECO:0000269PubMed:17707236}.
Subcellular Localization Nucleus {ECO:0000250UniProtKB:Q9EST4}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue. {ECO:0000269PubMed:11854909}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007094 mitotic spindle assembly checkpoint
GO:0043066 negative regulation of apoptotic process
GO:0043248 proteasome assembly
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR016562 Proteasome assembly chaperone 2, eukaryotic
IPR019151 Proteasome assembly chaperone 2
PFAM PF09754
PRINTS
PIRSF PIRSF010044
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969U7
PhosphoSite PhosphoSite-Q969U7
TrEMBL V9GYH7
UniProt Splice Variant
Entrez Gene 56984
UniGene Hs.464652
RefSeq NP_064617
HUGO HGNC:24929
OMIM 609702
CCDS CCDS11862
HPRD 11638
IMGT
EMBL AF276707 AK057005 AP005482 BC013356 BR000237 CH471113 CR457181 EF445040
GenPept AAH13356 AAK69439 ACA06090 BAG51841 CAG33462 EAX01540 EAX01541 FAA00023

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca