InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC6A3

Summary

InnateDB Protein

IDBP-11163.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A3

Protein Name

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Synonyms

DAT; DAT1; PKDYS;

Species

Homo sapiens

Ensembl Protein

ENSP00000270349

InnateDB Gene

IDBG-11161 (SLC6A3)

Protein Structure

UniProt Annotation

Function

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO:0000269PubMed:15505207}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15505207}; Multi-pass membrane protein {ECO:0000269PubMed:15505207}.

Disease Associations

Parkinsonism-dystonia infantile (PKDYS) [MIM:613135]: A neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs. {ECO:0000269PubMed:19478460}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in substantia nigra. {ECO:0000269PubMed:7637582}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005102	receptor binding
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005329	dopamine transmembrane transporter activity
GO:0005330	dopamine:sodium symporter activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008504	monoamine transmembrane transporter activity
GO:0032403	protein complex binding
GO:0035240	dopamine binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0007568	aging
GO:0007595	lactation
GO:0007608	sensory perception of smell
GO:0007626	locomotory behavior
GO:0008219	cell death
GO:0010039	response to iron ion
GO:0014070	response to organic cyclic compound
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0021984	adenohypophysis development
GO:0035094	response to nicotine
GO:0040018	positive regulation of multicellular organism growth
GO:0042053	regulation of dopamine metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042220	response to cocaine
GO:0042416	dopamine biosynthetic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0051591	response to cAMP
GO:0055085	transmembrane transport
GO:0060134	prepulse inhibition

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body