Version 5.4
Homo sapiens Protein: PRSS22
Summary
InnateDB Protein IDBP-11110.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRSS22
Protein Name protease, serine, 22
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000161006
InnateDB Gene IDBG-11108 (PRSS22)
Protein Structure
UniProt Annotation
Function Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. {ECO:0000269PubMed:11602603}.
Subcellular Localization Secreted {ECO:0000269PubMed:11602603}.
Disease Associations
Tissue Specificity Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland. {ECO:0000269PubMed:11602603}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
PFAM PF00089
PF09342
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZN4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 64063
UniGene Hs.459709
RefSeq NP_071402
HUGO HGNC:14368
OMIM 609343
CCDS CCDS10481
HPRD 08336
IMGT
EMBL AB010779 AC003965 AF321182 AY358396 BC009726
GenPept AAB93671 AAG35070 AAH09726 AAQ88762 BAB20263

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca