Version 5.4
Homo sapiens Protein: PDLIM2
Summary
InnateDB Protein IDBP-11061.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM2
Protein Name PDZ and LIM domain 2 (mystique)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342035
InnateDB Gene IDBG-11055 (PDLIM2)
Protein Structure
UniProt Annotation
Function Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. {ECO:0000269PubMed:15659642}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15659642}. Nucleus {ECO:0000269PubMed:15659642}. Note=May be partially nuclear.Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).Isoform 2: Cytoplasm, cytoskeleton.Isoform 3: Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR001781 Zinc finger, LIM-type
PFAM PF00595
PF13180
PF00412
PRINTS
PIRSF
SMART SM00228
SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JY6
PhosphoSite PhosphoSite-Q96JY6
TrEMBL C9K0F0
UniProt Splice Variant
Entrez Gene 64236
UniGene Hs.632034
RefSeq
HUGO HGNC:13992
OMIM 609722
CCDS CCDS6032
HPRD 17831
IMGT
EMBL AC037459 AF289563 AK024498 AK027800 AK056748 AY007729 AY070438 AY217349 BC021556 BC071774 CH471080
GenPept AAG16633 AAH21556 AAH71774 AAL55747 AAL65265 AAO45102 BAB15788 BAB55378 BAG51802 EAW63667 EAW63669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca