InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP3CC

Summary

InnateDB Protein

IDBP-10935.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP3CC

Protein Name

protein phosphatase 3, catalytic subunit, gamma isozyme

Synonyms

CALNA3; CNA3; PP2Bgamma;

Species

Homo sapiens

Ensembl Protein

ENSP00000289963

InnateDB Gene

IDBG-10931 (PPP3CC)

Protein Structure

UniProt Annotation

Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Subcellular Localization

Disease Associations

Tissue Specificity

Testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005516	calmodulin binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt