InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD38

Summary

InnateDB Protein

IDBP-10672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD38

Protein Name

CD38 molecule

Synonyms

ADPRC 1; T10;

Species

Homo sapiens

Ensembl Protein

ENSP00000226279

InnateDB Gene

IDBG-10668 (CD38)

Protein Structure

UniProt Annotation

Function

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269PubMed:9074508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003953	NAD+ nucleosidase activity
GO:0016740	transferase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016849	phosphorus-oxygen lyase activity
GO:0050135	NAD(P)+ nucleosidase activity

Biological Process

GO:0001666	response to hypoxia
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007565	female pregnancy
GO:0008152	metabolic process
GO:0009725	response to hormone
GO:0030307	positive regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0032024	positive regulation of insulin secretion
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032570	response to progesterone
GO:0033194	response to hydroperoxide
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045779	negative regulation of bone resorption
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045907	positive regulation of vasoconstriction
GO:0050853	B cell receptor signaling pathway
GO:0060292	long term synaptic depression
GO:0070555	response to interleukin-1
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle